High Speed Ampoule Filling & Sealing Machine built on principle of slant travel of ampoules while filling and sealing, to take care of vide variation of ampoule neck dimensions, thicknesses of available standard ampoules. The Filling unit built on S. S. Square pipe frame and totally encompassed with S. S. Coverings, in pleasing matt finish, Further, the large opening available at the bottom side for ease of absolute cleaning. The pendant type electrical control panel is lifted from machine for ease of operation and safety.